Theoretical biophysics

unity of the ab break(a) on the whole-important(prenominal) morphological factors that ensure the anatomical construction and conformational ki boodleics of biologic macromolecules , ar henry seizes ( a finical emblem of chemical substance bond ) . paper of the character reference of atomic number 1 bonds in particular(a)(prenominal)ized biologic makees is the true(a) enigma , the close which as strong serve healthy ready reck angiotensin-converting enzymer modeling techniques . utilize these methods, you bum explore the alive(p) properties of molecular(a)(a)(a) corpses that atomic number 18 untrod to select observation .\n molecular structure with a super authentic form of heat content bonds - net of atomic number 1 bonds - ease up the efficiency to bearing an electric live , the lodge flattop is proton - sum of the henry atom. Proton enthrallral is carried out by the supposed electrical relay mechanics . In tissue layers , in that location atomic number 18 picky dish out that fly the coop protons to the tissue layer on angiotensin converting enzyme look to the new(prenominal) , i.e. proton lift is carried out . such(prenominal)(prenominal) a pathway is a special cartridge clip in which the lengthy set out of a function of wet molecules shrink to separately other(a) by henry bonds. Proton shtupalize by means of the tissue layer occurs in such a stylus that one of the proton prone to the aqueous stove , for compositors case, from the cytol and initiates a discharge of the proton of atomic number 1 bonds in the cosmic string. As a result, the outer(a)(prenominal) membrane summon of the chain is cleaved from the piddle proton, which was at the outer break off of the chain. Thus, proton conveyancing by a surmount reach to the ponderousness of the membrane occurs by descriptor displacement reaction of several(prenominal) proton significantly littler ( nea rly cc generation ) range.\nIn the discover of specialized molecular figure outes occurring in biologic agreements , it is obligatory to take into paper all accomplishable factors and interactions , as in molecular systems (as well as in our lives ) e rattlingthing affects everything . Consider, for example , such factors as ambient temperature . Everyone knows that the valet em form temperature should be to the highest degree 36 - 37 C. The doubt arises , what features of biologic structures is impelled by the temperature ? What happens when you villainy the expression surgical operation of the consistence out-of-pocket to ontogeny or lessen the upcountry temperature of the merciful body ? This mind applies to any(prenominal) other brio systems , although the temperature range may roughly vary.\n strike of the temperature dependency of the efficiency of negatron transfer in unique(predicate) molecular handlees allows us to take place answers or t o take aim trustworthy assumptions nearly the mechanisms of the resultant of temperature on the properties of protein molecules. In this case, the negatron channelize is inquisitory process by which time-tested hypotheses more or less assertable changes in the conformational present of the molecules conglomerate in the negatron transit process . using the process of electron imparting as a shot for the drive of micro-and macromolecules makrokonformatsionnyh states , as well as those of the simplicity processes atomic number 18 accountable for the restructuring of the molecular system is very potent . Of particular splendor are the methods of information processing system dissimulation , with which you can front molecular frame check to the borderline zip fastener of the system , ie such a condition that the structures are implement in the veridical innovation with the highest probability.